JoF, Free Full-Text

Por um escritor misterioso

Descrição

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus Paracoccidioides and the different clinical forms of the disease are associated with the host immune responses. Quantitative trait loci mapping analysis was performed to assess genetic variants associated with mononuclear-cells-derived cytokines induced by P. brasiliensis on 158 individuals. We identified the rs11053595 SNP, which is present in the CLEC7A gene (encodes the Dectin-1 receptor) and the rs62290169 SNP located in the PROM1 gene (encodes CD133) associated with the production of IL-1β and IL-22, respectively. Functionally, the blockade of the dectin-1 receptor abolished the IL-1β production in P. brasiliensis-stimulated PBMCs. Moreover, the rs62290169-GG genotype was associated with higher frequency of CD38+ Th1 cells in PBMCs cultured with P. brasiliensis yeasts. Therefore, our research indicates that the CLEC7A and PROM1 genes are important for the cytokine response induced by P. brasiliensis and may influence the Paracoccidioidomycosis disease outcome.
JoF, Free Full-Text
Journal of Fungi An Open Access Journal from MDPI
JoF, Free Full-Text
The Fungi 1 2 3 5.1 Million Species - Colaboratory
JoF, Free Full-Text
Loads of Free, Full-Text Nursing Journal Articles for Nurses Week [Six Days Only] – Nursetopia
JoF, Free Full-Text
Just Another Foundry – JAF Johannes
JoF, Free Full-Text
Open Access Journals - HTC Library
JoF, Free Full-Text
Free Full Text ( Final Version , 2mb ) (PDF) @ PDF Room
JoF, Free Full-Text
EBSCO Developer PublicationIQ Browse Database Overview
JoF, Free Full-Text
Sustainability, Free Full-Text
JoF, Free Full-Text
Jot Regular : Download For Free, View Sample Text, Rating And More On
de por adulto (o preço varia de acordo com o tamanho do grupo)